NCIt definition : A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic
potency. Daniplestim exhibits 10- to 20-fold greater biological activity than recombinant
human IL-3 in human hematopoietic cell proliferation and marrow colony-forming-unit
assays. In contrast, this agent shows no significant increase in pro-inflammatory
activity relative to native IL-3. The enhanced hematopoietic activity of daniplestim
correlates with a 60-fold increase in IL-3 alpha-subunit binding affinity and 20-fold
greater affinity for binding to alpha/beta receptor complexes on intact cells relative
to recombinant IL-3.;
UNII : 491EKS8W4C;
CAS number : 161753-30-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 161753-30-6
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