Daniplestim - CISMeF

Preferred Label : Daniplestim;

NCIt definition : A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater biological activity than recombinant human IL-3 in human hematopoietic cell proliferation and marrow colony-forming-unit assays. In contrast, this agent shows no significant increase in pro-inflammatory activity relative to native IL-3. The enhanced hematopoietic activity of daniplestim correlates with a 60-fold increase in IL-3 alpha-subunit binding affinity and 20-fold greater affinity for binding to alpha/beta receptor complexes on intact cells relative to recombinant IL-3.;

UNII : 491EKS8W4C;

CAS number : 161753-30-6;

Drug name : Synthokine;

Molecule name : SC-55494;

Details

Origin ID

C60775;

UMLS CUI

C0297038;

Currated CISMeF NLP mapping
- daniplestim [MeSH concept]
- daniplestim [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- daniplestim [MeSH Supplementary Concept]
- daniplestim [MeSH concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_target
- Interleukin 3 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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