CAD Protein - CISMeF

Preferred Label : CAD Protein;

NCIt synonyms : Glutamine-Dependent Carbamoyl-Phosphate Synthase/Aspartate Carbamoyltransferase/Dihydroorotase; Aspartate Carbamoyltransferase;

NCIt definition : CAD protein (2225 aa, 293 kDa) is encoded by the human CAD gene. This protein is involved in pyrimidine biosynthesis.;

NCIt note : CAD protein forms a homohexamer and has four enzymatic activities: glutamine amidotransferase, carbamoyl phosphate synthase, aspartate carbamoyltransferase and dihydroorotase. The activities of the CAD protein have IUBMB designations of EC 6.3.5.5, EC 2.1.3.2, and EC 3.5.2.3. (UniProt);

Details

Origin ID

C38927;

UMLS CUI

C3642322;

Currated CISMeF NLP mapping
- Aspartate carbamoyltransferase (substance) [SNOMED CT concept]
- aspartate carbamoyltransferase [MeSH Descriptor]
- aspartate carbamoyltransferase [MeSH concept]
- aspartate carbamoyltransferase [SNOMED Notion]
OMIM relation
- Carbamoyl phosphate synthetase/aspartate transcarbamylase/dihydroorotase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- CAD Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Sparfosic Acid [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alanine, Aspartate and Glutamate Metabolism Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Nucleotide Biosynthesis Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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