NCIt definition : A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction
with antineoplastic activity. Sparfosic acid is a stable transition analogue of the
activated complex for the reaction catalyzed by aspartate transcarbamylase, the first
step in the pyrimidine biosynthetic pathway. This agent inhibits de novo pyrimidine
biosynthesis and increases the extent to which fluorouracil metabolites are incorporated
into RNA.;
Alternative definition : NCI-GLOSS: An anticancer drug that is being studied to increase the effectiveness
of the chemotherapy drug fluorouracil.;