" /> Sparfosic Acid - CISMeF





Preferred Label : Sparfosic Acid;

NCIt synonyms : Sparfosate; PALA; N-Phosphonacetyl-L-aspartate; Phosphonacetyl-L-aspartic Acid; L-Aspartic acid, N-(phosphonoacetyl)-;

NCIt definition : A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable transition analogue of the activated complex for the reaction catalyzed by aspartate transcarbamylase, the first step in the pyrimidine biosynthetic pathway. This agent inhibits de novo pyrimidine biosynthesis and increases the extent to which fluorouracil metabolites are incorporated into RNA.;

Alternative definition : NCI-GLOSS: An anticancer drug that is being studied to increase the effectiveness of the chemotherapy drug fluorouracil.;

UNII : 78QVZ7RG8L;

InChIKey : ZZKNRXZVGOYGJT-VKHMYHEASA-N;

CAS number : 51321-79-0;

Chemical formula : C6H10NO8P;

NSC code : 224131;

Codes from synonyms : CDR0000045231; NSC0224131;

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28/05/2025


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