Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway

Preferred Label : Glycosylphosphatidylinositol-Anchor Biosynthesis Pathway;

NCIt synonyms : GPI-Anchor Biosynthesis Pathway;

NCIt related terms : Glycosylphosphatidylinositol (GPI)-anchor Biosynthesis;

Alternative definition : KEGG: Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis genes result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.;

KEGG ID : hsa00563;

Details

Origin ID

C38822;

UMLS CUI

C1512236;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- GPI Ethanolamine Phosphate Transferase 1 [NCIt concept]
- Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein [NCIt concept]
- Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A [NCIt concept]
- Phosphatidylinositol-Glycan Biosynthesis Class F Protein [NCIt concept]
pathway_has_gene_element
- PIGA wt Allele [NCIt concept]
- PIGF wt Allele [NCIt concept]
- PIGN wt Allele [NCIt concept]
- PIGU wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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