Lorvotuzumab Mertansine

Preferred Label : Lorvotuzumab Mertansine;

NCIt synonyms : Anti-Human NCAM-1 Monoclonal Antibody N901; huN901-DM1;

NCIt related terms : BB-10901;

NCIt definition : An immunoconjugate of a humanized murine monoclonal antibody (huN-901) and DMI, a semi-synthetic derivative of the plant-derived ansa macrolide maytansine. The antibody moiety of BB-10901 selectively attaches to CD56 antigen, a neural cell adhesion molecule (NCAM)) expressed on the surface of cells of small cell lung cancer (SCLC) and other neuroendocrine (NE) tumors. Thus, the DMI conjugate is targeted specifically to CD56-expressing tumor cells, where it inhibits tubulin polymerization and assembly, resulting in inhibition of mitosis and cell cycle arrest in the S phase. (NCI04);

Alternative definition : NCI-GLOSS: A substance that combines a monoclonal antibody (huN901) with an anticancer drug (DM1), and is being studied in the treatment of certain cancers, including non-small cell lung cancer. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.;

UNII : 0IVD6ASY0W;

CAS number : 1008106-64-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1008106-64-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : IMGN901; BB-10901;

Codes from synonyms : CDR0000350225;

Details

Origin ID

C38714;

UMLS CUI

C2987530;

Automatic exact mappings (from CISMeF team)
- Ado-Trastuzumab Emtansine [MeSH Descriptor]
Currated CISMeF NLP mapping
- huN901-DM1 [MeSH concept]
- lorvotuzumab mertansine [MeSH concept]
- lorvotuzumab mertansine [MeSH Supplementary Concept]
See also inter- (CISMeF)
- NCAM1 protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- lorvotuzumab mertansine [MeSH Supplementary Concept]
- lorvotuzumab mertansine [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Neural Cell Adhesion Molecule 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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