Preferred Label : Adenosine Receptor A1;
NCIt synonyms : Adenosine A1 Receptor; ADORA1; Adenosine-A1 Receptor;
NCIt definition : Adenosine receptor A1 (326 aa, 37 kDa) is encoded by the human ADORA1 gene. This
protein is involved in signal transduction, apoptosis, phagocytosis, inflammatory
response and nervous system development.;
NCIt note : Widely expressed (ubiquitous in CNS) by human ADORA1 Gene (GPCR1 Family), conserved
326-aa 37-kDa Adenosine A1 Receptor is a cell-surface integral membrane protein containing
7 transmembrane domains that interacts with a heterotrimeric G protein complex in
response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase
inhibition and regulate diverse physiologic functions including cardiac rate and contractility,
smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis,
renal function, white blood cell function, and spermatozoal capacitation. ADORA1 appears
to colocalize with adenosine deaminase, which may be necessary for high affinity agonist
binding. A potent biologic mediator, most effects of adenosine protect cells during
stress.;
Origin ID : C38610;
UMLS CUI : C5441600;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
