Adenosine Receptor A1

Preferred Label : Adenosine Receptor A1;

NCIt synonyms : Adenosine A1 Receptor; ADORA1; Adenosine-A1 Receptor;

NCIt definition : Adenosine receptor A1 (326 aa, 37 kDa) is encoded by the human ADORA1 gene. This protein is involved in signal transduction, apoptosis, phagocytosis, inflammatory response and nervous system development.;

NCIt note : Widely expressed (ubiquitous in CNS) by human ADORA1 Gene (GPCR1 Family), conserved 326-aa 37-kDa Adenosine A1 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition and regulate diverse physiologic functions including cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation. ADORA1 appears to colocalize with adenosine deaminase, which may be necessary for high affinity agonist binding. A potent biologic mediator, most effects of adenosine protect cells during stress.;

Details

Origin ID

C38610;

UMLS CUI

C5441600;

Currated CISMeF NLP mapping
- receptor, adenosine A1 [MeSH concept]
- receptor, adenosine a1 [MeSH Descriptor]
OMIM relation
- Adenosine a1 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptor, adenosine A1 [MeSH concept]
- receptor, adenosine a1 [MeSH Descriptor]
gene_encodes_gene_product
- ADORA1 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Purinergic P1 Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Blood Circulation [NCIt concept]
- Cell Defense Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Inflammatory Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Nervous System Development [NCIt concept]
- Perception [NCIt concept]
- Phagocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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