NCIt definition : Thymidine kinase 2, mitochondrial (265 aa, 31 kDa) is encoded by the human TK2 gene.
This protein is involved in mitochondrial pyrimidine metabolism.;
NCIt note : mtDNA synthesis depends on 2 salvage pathway deoxyribonucleoside kinases, DGK and
TK2. Separated from cytosolic dNTPs by the mitochondria inner membrane, mitochondrial
dNTPs are maintained by transporter import or deoxynucleoside salvaging; de novo dNTP
synthetic enzymes appear not to be present in mitochondria.;