Thymidine Kinase, Mitochondrial

Preferred Label : Thymidine Kinase, Mitochondrial;

NCIt synonyms : Mt-TK; TK2; Mitochondrial Thymidine Kinase 2; Thymidine Kinase-2; EC 2.7.1.21; Thymidine Kinase 2;

NCIt definition : Thymidine kinase 2, mitochondrial (265 aa, 31 kDa) is encoded by the human TK2 gene. This protein is involved in mitochondrial pyrimidine metabolism.;

NCIt note : mtDNA synthesis depends on 2 salvage pathway deoxyribonucleoside kinases, DGK and TK2. Separated from cytosolic dNTPs by the mitochondria inner membrane, mitochondrial dNTPs are maintained by transporter import or deoxynucleoside salvaging; de novo dNTP synthetic enzymes appear not to be present in mitochondria.;

Détails

Origin ID

C38513;

UMLS CUI

C0537740;

Automatic exact mappings (from CISMeF team)
- Thymidine kinase, mitochondrial [OMIM gene]
- Transfer rna, mitochondrial, lysine [OMIM gene]
- mitochondrially encoded tRNA-Lys (AAA/G) [ORDO Gene]
- thymidine kinase 2 [HGNC gene]
OMIM relation
- Thymidine kinase, mitochondrial [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- thymidine kinase 2 [MeSH Supplementary Concept]
- thymidine kinase 2 [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- TK2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrial Matrix [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Synthesis [NCIt concept]
- Phosphorylation Process [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

Vous pouvez consulter :

recommendations
documents concerning education
documents for patients