Thymidine Kinase, Cytosolic

Preferred Label : Thymidine Kinase, Cytosolic;

NCIt synonyms : Cytosolic Thymidine Kinase; Soluble Thymidine Kinase 1; TK1; Thymidine Kinase-1; EC 2.7.1.21; Thymidine Kinase 1;

NCIt definition : Thymidine kinase, cytosolic (234 aa, 25 kDa) is encoded by the human TK1 gene. This protein plays a role in pyrimidine metabolism.;

NCIt note : The enzymatic activity of thymidine kinase, cytosolic is tied to the cell cycle. Its activity is high in proliferating cells and peaks during the S-phase of the cell cycle, while resting cells demonstrate low activity. (UniProt);

Details

Origin ID

C38512;

UMLS CUI

C1522555;

OMIM relation
- Thymidine kinase, soluble [OMIM gene]
See also inter- (CISMeF)
- thymidine kinase 2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TK1 protein, human [MeSH concept]
Validated automatic mappings to NTBT
- thymidine kinase 1 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- TK1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Process [NCIt concept]
- Phosphorylation Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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