Preferred Label : Colchicine;
NCIt related terms : (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;
NCIt definition : An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory
activities. The exact mechanism of action by which colchicines exerts its effect has
not been completely established. Colchicine binds to tubulin, thereby interfering
with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting
mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory
cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine
may also interrupt the cycle of monosodium urate crystal deposition in joint tissues,
thereby also preventing the resultant inflammatory response. Overall, colchicine decreases
leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the
formation and release of a chemotactic glycoprotein that is produced during phagocytosis
of urate crystals.;
Alternative definition : NCI-GLOSS: A drug used to treat gout (inflamed joints caused by a buildup of uric
acid). It comes from the crocus plant Colchicum autumnale. Colchicine blocks cell
division and the movement of certain immune cells to areas that are inflamed. It is
a type of alkaloid and a type of mitotic inhibitor.;
UNII : SML2Y3J35T;
InChIKey : IAKHMKGGTNLKSZ-INIZCTEOSA-N;
CAS number : 64-86-8;
Drug name : Mitigare; Colcrys;
Chemical formula : C22H25NO6;
NSC code : 757;
ChEBI ID : CHEBI:27882;
Codes from synonyms : NSC0000757; CDR0000648949; 02760; 34403;
Origin ID : C385;
UMLS CUI : C0009262;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
https://www.rheuma-net.ch/fr/doc/colchicine/viewdocument/491
2024
Switzerland
guideline
Background Treatment
colchicine
colchicine
Colchicine
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