Troponin T - CISMeF

Preferred Label : Troponin T;

NCIt synonyms : TNNT;

NCIt definition : Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle. The complex serves as a calcium-sensitive switch that regulates muscle contraction. Troponin T binds tropomyosin to the troponin complex and inhibits F-actin-myosin interactions. The troponin T gene family comprises three isoforms: slow skeletal (TNNT1), cardiac (TNNT2) and fast skeletal (TNNT3). Because it is not normally found in blood, cardiac troponin-T in serum is a sensitive indicator of myocardial cell injury.;

Details

Origin ID

C38041;

UMLS CUI

C0077404;

Currated CISMeF NLP mapping
- Troponin T [MedDRA Preferred Term]
- Troponin T (substance) [SNOMED CT concept]
- Troponin-T [FMA entity]
- troponin T [MeSH concept]
- troponin t [MeSH Descriptor]
- troponin t [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Troponin T [LOINC component]
- Troponin T (substance) [SNOMED CT concept]
- Troponin-T [FMA entity]
- troponin T [MeSH concept]
- troponin t [MeSH Descriptor]
- troponin t [SNOMED Notion]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Movement Process [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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