Haptoglobin - CISMeF

Preferred Label : Haptoglobin;

NCIt synonyms : HP; Zonulin;

NCIt definition : Haptoglobin (406 aa, 45 kDa) is encoded by the human HP gene. This protein plays a role in tight junction disassembly, intestinal permeability, heme iron recycling, antimicrobial activity and the regulation of hydrogen peroxide catabolism.;

NCIt note : Binding free plasma hemoglobin, secreted haptoglobin prevents loss of iron through the kidneys, protects the kidneys from oxidative damage by hemoglobin (Hb), and makes hemoglobin accessible to degradative enzymes. Hp/Hb clearance appears to be mediated by the monocyte/macrophage scavenger receptor CD163. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, by allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. (UniProt); Although homologous to serine proteases, haptoglobin is missing all of the essential catalytic residues; therefore, it has no enzymatic activity. (UniProt);

Details

Origin ID

C37962;

UMLS CUI

C1505203;

Automatic exact mappings (from CISMeF team)
- Haptoglobin [OMIM gene]
- Haptoglobin increased [MedDRA Preferred Term]
- Hypersensitivity pneumonitis [ORDO Disease]
- Milligram/deciliter haptoglobin (qualifier value) [SNOMED CT concept]
- Pancreatitis, hereditary [OMIM Phenotype]
- Zonulin [LOINC component]
- haptoglobin [HGNC gene]
- haptoglobin [COVID-19 Thesaurus concept]
- haptoglobin [medical devices type]
- helicobacter pylori [MeSH Descriptor]
- hermanski-pudlak syndrome [MeSH Descriptor]
- hospitals, psychiatric [MeSH Descriptor]
- pituitary gland [UBERON concept]
- zonulin [MeSH concept]
- zonulin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Haptoglobin [LOINC component]
- Haptoglobin [MedDRA Preferred Term]
- Haptoglobin (substance) [SNOMED CT concept]
- haptoglobin, nos [SNOMED Notion]
- haptoglobins [MeSH Descriptor]
- haptoglobins [MeSH concept]
OMIM relation
- Haptoglobin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HP protein, human [MeSH concept]
- HP protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HP Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Defense Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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