Matrix Gla Protein

Preferred Label : Matrix Gla Protein;

NCIt synonyms : MGP; MGLAP; Gamma-Carboxyglutamic Acid Protein, Matrix; Cell Growth-Inhibiting Gene 36 Protein; Matrix Gamma-Carboxyglutamic Acid Protein;

NCIt definition : Matrix Gla protein (103 aa, 12 kDa) is encoded by the human MGP gene. This protein plays a role in the regulation of bone formation and the inhibition of tissue calcification.;

NCIt note : The vitamin K-dependent gamma-carboxylation status of matrix Gla protein may be inversely correlated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. (EntrezGene);

Details

Origin ID

C33942;

UMLS CUI

C1505267;

OMIM relation
- Matrix gamma-carboxyglutamic acid [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MGP protein, human [MeSH concept]
- matrix gla protein [MeSH concept]
- matrix gla protein [MeSH Supplementary Concept]
gene_encodes_gene_product
- Extracellular Matrix Protein Gene [NCIt concept]
- MGP Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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