Retinal Pigment Epithelium

Preferred Label : Retinal Pigment Epithelium;

NCIt synonyms : RPE;

NCIt related terms : RETINAL PIGMENTED EPITHELIAL LAYER;

NCIt definition : A continuous, insulating monolayer of cuboidal/columnar epithelium which extends from the margins of the optic nerve head to the ora serrata where it is continuous with the pigment epithelium of the pars plana. This cell layer has many physical, optical, metabolic/biochemical and transport functions which play a critical role in the normal visual process, including acting as a selective filter to determine what nutrients reach the retina from the choroid.;

Alternative definition : CDISC: A continuous, insulating monolayer of cuboidal/columnar epithelium which extends from the margins of the optic nerve head to the ora serrata where it is continuous with the pigment epithelium of the pars plana. (NCI);

Details

Origin ID

C33470;

UMLS CUI

C0035322;

Anatomic structure is physical part of
- Retina [NCIt concept]
Associated anatomy of gene products
- G-Protein Coupled Receptor 143 [NCIt concept]
Automatic exact mappings (from CISMeF team)
- Pigmented layer of retina [FMA entity]
- Retinal pigment epithelium [LOINC System]
- Ribulose 5-phosphate 3-epimerase [OMIM gene]
- Strain RPE (qualifier value) [SNOMED CT concept]
- Structure of retinal pigment epithelium (body structure) [SNOMED CT concept]
- pigment epithelium of retina [SNOMED Notion]
- pigmented layer of retina [UBERON concept]
Currated CISMeF NLP mapping
- retinal pigment epithelium [MeSH Descriptor]
- retinal pigment epithelium [MeSH concept]
Semantic type(s)
- Body Part, Organ, or Organ Component [UMLS semantic type]
UMLS correspondences (same concept)
- Pigmented layer of retina [FMA entity]
- Retinal pigment epithelium [LOINC System]
- Structure of retinal pigment epithelium (body structure) [SNOMED CT concept]
- pigment epithelium of retina [SNOMED Notion]
- pigmented layer of retina [Radlex concept]
- pigmented layer of retina [UBERON concept]
- retinal pigment epithelium [MeSH concept]
- retinal pigment epithelium [MeSH Descriptor]
concept_is_in_subset
- CDISC SDTM Anatomical Location Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CDISC SEND Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
is_normal_tissue_origin_of_disease
- Adenoma of the Retinal Pigment Epithelium [NCIt concept]
- Retinal Pigment Epithelium Adenocarcinoma [NCIt concept]
tissue_is_expression_site_of_gene_product
- Bestrophin-1 [NCIt concept]
- Beta,Beta-Carotene 15,15'-Dioxygenase [NCIt concept]
- Monocarboxylate Transporter 3 [NCIt concept]
- Myosin-IIIa [NCIt concept]

Keyword's position in hierarchy(ies) :

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