Multiple Endocrine Neoplasia Type 1

Preferred Label : Multiple Endocrine Neoplasia Type 1;

NCIt synonyms : Multiple Endocrine Neoplasia, Type I; MEA Type 1; Multiple Endocrine Adenomatosis, Type I; MEN 1; Multiple Endocrine Adenomatosis Type 1; Wermer's Syndrome; MEN Type I; Multiple Endocrine Adenomatosis Type I; MEA Type I; MEN Type 1; Multiple Endocrine Neoplasia Type I;

NCIt related terms : Wermer syndrome; Multiple Endocrine Adenomatosis; MEN1 syndrome; multiple endocrine neoplasia type 1 syndrome; Multiple endocrine neoplasia [MEN] type I;

NCIt definition : Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, pancreatic islet cell neoplasms, and carcinoid tumors.;

Alternative definition : NICHD: Multiple endocrine neoplasia caused by inactivating mutation(s) of the tumor suppressor gene MEN1, encoding the menin protein, a component of the histone methyltransferase complex. The condition is characterized by hyperfunctioning adenomas of the parathyroid glands, adrenal glands, pituitary gland, and pancreatic endocrine cells (most commonly gastrinomas and insulinomas); thymic and bronchial carcinoid tumors also may develop.; NCI-GLOSS: A rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign (not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant (cancer).;

Neoplastic status : Undetermined;

Codes from synonyms : CDR0000270862; CDR0000270861; CDR0000270864; E31.21;

Details

Origin ID

C3225;

UMLS CUI

C0025267;

Currated CISMeF NLP mapping
- MEA Type I [MedDRA LLT]
- MEN Type I [MedDRA LLT]
- Multiple endocrine adenomatosis Type I [MedDRA LLT]
- Multiple endocrine neoplasia Type 1 [MedDRA Preferred Term]
- Multiple endocrine neoplasia Type I [MedDRA LLT]
- Multiple endocrine neoplasia [MEN] type I [ICD-9 code]
- Multiple endocrine neoplasia type 1 [ICD-11 More detail]
- Multiple endocrine neoplasia type 1 [ORDO Disease]
- Multiple endocrine neoplasia type I [PASCAL descriptor]
- Multiple endocrine neoplasia, type 1 (disorder) [SNOMED CT concept]
- Multiple endocrine neoplasia, type I [OMIM Phenotype]
- multiple endocrine neoplasia type 1 [DO Concept]
- multiple endocrine neoplasia type 1 [Disease (Nov.)]
- multiple endocrine neoplasia type 1 [MeSH Descriptor]
- multiple endocrine neoplasia type 1 [MeSH concept]
- multiple endocrine neoplasia, type 1 [SNOMED Notion]
DO Cross reference
- multiple endocrine neoplasia type 1 [DO Concept]
Disease excludes abnormal cell
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease excludes normal cell origin
- Thyroid Gland Follicular Cell [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- MEA Type I [MedDRA LLT]
- MEN Type I [MedDRA LLT]
- Multiple endocrine adenomatosis Type I [MedDRA LLT]
- Multiple endocrine neoplasia Type 1 [MedDRA Preferred Term]
- Multiple endocrine neoplasia Type I [MedDRA LLT]
- Multiple endocrine neoplasia [MEN] type I [ICD-9 code]
- Multiple endocrine neoplasia type 1 [ORDO Disease]
- Multiple endocrine neoplasia, type 1 (disorder) [SNOMED CT concept]
- Multiple endocrine neoplasia, type I [OMIM Phenotype]
- multiple endocrine neoplasia type 1 [DO Concept]
- multiple endocrine neoplasia type 1 [Disease (Nov.)]
- multiple endocrine neoplasia type 1 [MeSH concept]
- multiple endocrine neoplasia type 1 [MeSH Descriptor]
- multiple endocrine neoplasia, type 1 [SNOMED Notion]
Validated automatic mappings to NTBT
- Multiple endocrine adenomatosis [MedDRA LLT]
- multiple endocrine neoplasia [MeSH Descriptor]
- multiple endocrine neoplasia [DO Concept]
associated_with_malfunction_of_gene_product
- Menin [NCIt concept]
concept_is_in_subset
- CCPS Disease Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- Childhood Cancer Predisposition Study Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Endocrinology Terminology [NCIt concept]
- mCode Elixhauser Malignant Solid Tumors without Metastases Value Set [NCIt concept]
- mCode Terminology [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
disease_has_finding
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Multifocal Lesion [NCIt concept]
disease_has_molecular_abnormality
- MEN1 Gene Inactivation [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_mapped_to_gene
- MEN1 Gene [NCIt concept]
disease_may_have_associated_disease
- Duodenal Gastrin-Producing Neuroendocrine Tumor [NCIt concept]
- Foregut Neuroendocrine Tumor [NCIt concept]
- Pancreatic Neuroendocrine Neoplasm [NCIt concept]
- Parathyroid Gland Adenoma [NCIt concept]
- Pituitary Neuroendocrine Tumor [NCIt concept]
may_be_associated_disease_of_disease
- Malignant Pancreatic Vipoma [NCIt concept]
- Pancreatic Vipoma [NCIt concept]
pathogenesis_of_disease_involves_gene
- MEN1 Gene [NCIt concept]
- MEN1 wt Allele [NCIt concept]
related_to_genetic_biomarker
- MEN1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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