Protein Unc-13 Homolog B

Preferred Label : Protein Unc-13 Homolog B;

NCIt synonyms : UNC13; Munc13 Homolog; UNC-13-Like; munc13; UNC-13 Homolog B; Munc13-2; UNC-13 Homolog-B Protein;

NCIt definition : Protein unc-13 homolog B (1591 aa, 181 kDa) is encoded by the human UNC13B gene. This protein is involved in exocytosis.;

NCIt note : UNC13 is a putative DAG receptor and may act in a PKC-independent DAG-activated apoptosis pathway. UNC13 also appears to be a presynaptic protein that promotes synaptic vesicle priming by acting through syntaxin. Post-docking synaptic vesicle exocytosis priming requires SNARE complex formation. The default closed syntaxin configuration is incompatible with SNARE formation; the N-terminus binds the SNARE motif and occludes SNARE protein interactions. UNC13 binding to the syntaxin N-terminus may promote an open syntaxin configuration and prime synaptic vesicles for fusion.;

Details

Origin ID

C30151;

UMLS CUI

C1436571;

OMIM relation
- Unc13 homolog b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- UNC13B protein, human [MeSH concept]
- UNC13B protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
- UNC13B Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Synapse [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Exocytosis [NCIt concept]
- Ligand Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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