Nicotinamide Phosphoribosyltransferase

Preferred Label : Nicotinamide Phosphoribosyltransferase;

NCIt synonyms : Pre-B Cell Enhancing Factor; PBEF; Pre-B Cell-Enhancing Factor; Pre-B-Cell Colony-Enhancing Factor; Nampt; EC 2.4.2.12; Visfatin; Pre-B-Cell Colony-Enhancing Factor 1; Pre-B-Cell Colony Enhancing Factor 1; NAmPRTase;

NCIt definition : Nicotinamide phosphoribosyltransferase (491 aa, 56 kDa) is encoded by the human NAMPT gene. This protein plays a role in both NAD biosynthesis and immunomodulation.;

NCIt note : Under non-inflammatory conditions, nicotinamide phosphoribosyltransferase predominantly exhibits a granular pattern within the nucleus. Following interleukin-1 beta stimulation, the protein is secreted. (UniProt);

Details

Origin ID

C30138;

UMLS CUI

C1571622;

OMIM relation
- Nicotinamide phosphoribosyltransferase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- nicotinamide phosphoribosyltransferase, human [MeSH concept]
- nicotinamide phosphoribosyltransferase, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Glycosyltransferase Gene [NCIt concept]
- NAMPT Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Nicotinate and Nicotinamide Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Glycosylation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- NAMPT Inhibitor OT-82 [NCIt concept]
- NAMPT Inhibitor STF-118804 [NCIt concept]
- Padnarsertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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