NCIt definition : A small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD)-synthesizing
enzyme nicotinamide phosphoribosyltransferase (NAMPT; NAMPRTase), with potential antineoplastic
activity. Upon administration, NAMPT inhibitor STF-118804 binds to and inhibits the
activity of NAMPT. This depletes cellular NAD and inhibits NAD-dependent enzymes,
both of which are needed for rapid cell proliferation, which may result in cell death
in NAMPT-overexpressing tumor cells. NAMPT, an enzyme that is responsible for maintaining
the intracellular NAD pool, plays a key role in the regulation of cellular metabolism
and has cytokine-like activities. NAMPT is overexpressed in a variety of cancers and
metabolic disorders; tumor cells rely on NAMPT activity for their NAD supply.;
Semantic type(s)