Proton Pump Inhibitor

Preferred Label : Proton Pump Inhibitor;

NCIt synonyms : PPI;

NCIt related terms : Proton Pump Inhibitors;

NCIt definition : Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H /K -ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion.;

Alternative definition : NICHD: A pharmaceutical agent that inhibits the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. These drugs are used for their anti-ulcer activity.;

ChEBI ID : CHEBI:49200;

Details

Origin ID

C29723;

UMLS CUI

C0358591;

Automatic exact mappings (from CISMeF team)
- Hydrogen/potassium adenosine triphosphatase enzyme system inhibitor (disposition) [SNOMED CT concept]
- Proton pump inhibitors [ICD-11 Extension code]
- infusion pumps, implantable [MeSH Descriptor]
- phosphatidylinositols [MeSH Descriptor]
- prepulse inhibition [GO term]
Currated CISMeF NLP mapping
- Product containing hydrogen/potassium adenosine triphosphatase enzyme system inhibitor (product) [SNOMED CT concept]
- Substance with hydrogen/potassium adenosine triphosphatase enzyme system inhibitor mechanism of action (substance) [SNOMED CT concept]
- proton pump inhibitors [Artificial nutrition thesaurus concept]
- proton pump inhibitors [MeSH Descriptor]
- proton pump inhibitors [MeSH concept]
- proton-pump inhibitors [CISMeF Querying Strategy]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- proton pump inhibitors [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Rheumatology Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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