NCIt definition : A substituted benzimidazole and proton pump inhibitor with antacid activity. Pantoprazole
is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic
parietal cell canaliculus where it becomes protonated, producing the active metabolite
sulphenamide, which forms an irreversible covalent bond with two sites of the H /K
-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal
and stimulated gastric acid production.;