Preferred Label : Killer Cell Lectin-Like Receptor Subfamily B Member 1;
NCIt synonyms : CD161 Antigen; NKRP1A Protein; NKR-P1; Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Protein; KLRB1; Natural Killer Cell Surface Protein P1A; NKR; CD161; Killer Cell Lectin-Like Receptor Subfamily B, Member 1; hNKR-P1A; C-Type Lectin Domain Family 5 Member B; NKR-P1A;
NCIt definition : Killer cell lectin-like receptor subfamily B member 1 (225 aa, 25 kDa) is encoded
by the human KLRB1 gene. This protein plays a role in the modulation of natural killer
cell cytotoxicity.;
NCIt note : Encoded by human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) and preferentially
expressed by natural killer lymphocytes and some peripheral T-cells, the type II membrane
NKRP1A Protein (external C-terminus) contains a 158-amino acid extracellular domain
with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid
cytoplasmic domain. C-type lectins, including NKRP1 glycoproteins, may regulate NK
cell function. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical
to human NKG2A. (from LocusLink, OMIM, and NCI);
Origin ID : C26477;
UMLS CUI : C1689853;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
- is_target
