Preferred Label : Rezorstobart;
NCIt synonyms : Anti-CD161 Monoclonal Antibody IMT-009;
NCIt definition : An Fc-attenuated human immunoglobulin G1 (IgG1) monoclonal antibody directed against
the C-type lectin-like receptor cluster of differentiation 161 (CD161), with potential
immunomodulatory and antineoplastic activities. Upon administration, rezorstobart
selectivity targets, binds to and blocks CD161. This disrupts the interaction of CD161
with its ligand lectin-like transcript-1 (CLEC2D; LLT1; OCIL), prevents CD161-mediated
signaling, abrogates the CLEC2D/ CD161-mediated suppression of CD161-positive T- and
natural killer (NK) cells, and restores the activation of effector functions of both
CD161-positive T- and NK cells against tumor cells, thereby enhancing cytotoxicity
towards tumor cells. CD161, an inhibitory immune checkpoint, is broadly expressed
on NK and a subset of memory CD4 and CD8 T-cells. It plays a key role in cancer
immune surveillance and its expression is associated with many types of cancer. CLEC2D
is expressed on the surface of both malignant cells and immune cells, including activated
B-cells and myeloid cells.;
UNII : Q3SE2QPZ2H;
CAS number : 2762201-86-3;
Molecule name : IMT-009; IMT 009;
NCI Metathesaurus CUI : CL1906519;
Origin ID : C199611;
UMLS CUI : C5854434;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
