Canfosfamide Hydrochloride

Preferred Label : Canfosfamide Hydrochloride;

NCIt related terms : Telcyta; TLK286;

NCIt definition : The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glutathione analogs.;

UNII : 1LI341K7NQ;

InChIKey : NECZZOFFLFZNHL-XVGZVFJZSA-N;

CAS number : 439943-59-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 439943-59-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Telcyta;

Molecule name : TLK286;

Chemical formula : C26H40Cl4N5O10PS.HCl;

Codes from synonyms : CDR0000413732; CDR0000038367; CDR0000045037;

Details

Origin ID

C2641;

UMLS CUI

C2930598;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- canfosfamide HCl [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Canfosfamide [NCIt concept]
is_component_of_chemotherapy_regimen
- Docetaxel/TLK286 [NCIt concept]
is_salt_form_of
- Canfosfamide [NCIt concept]

Keyword's position in hierarchy(ies) :

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