" /> Canfosfamide - CISMeF





Preferred Label : Canfosfamide;

NCIt synonyms : (2R)-L-gamma-Glutamyl-3-((2-((bis(bis(2-chloroethyl)amino)phosphinyl)oxy)ethyl)sulfonyl)-L-alanyl-2-phenylglycine;

NCIt definition : A modified glutathione analogue and nitrogen mustard prodrug, with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor cell proliferation. Glutathione S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.;

UNII : 1RS284BFUI;

InChIKey : OJLHWPALWODJPQ-QNWVGRARSA-N;

CAS number : 158382-37-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 158382-37-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : Ter 286;

Chemical formula : C26H40Cl4N5O10PS;

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15/05/2024


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