Preferred Label : Galectin-3-Binding Protein;
NCIt synonyms : Lectin, Galactoside-Binding, Soluble, 3 Binding Protein; MAC2BP; MAC2-Binding Protein; LGALS3BP; LGALS3BP Protein; Mac-2-Binding Protein; L3 Antigen; Serum Protein 90K; Basement Membrane Autoantigen p105; Lectin Galactoside-Binding Soluble 3-Binding Protein; Transport and Golgi Organization 10 Homolog B; Mac-2 BP; Galectin 3 Binding Protein; Galectin-3 Binding Protein; Tumor-Associated Antigen 90K;
NCIt definition : Galectin-3-binding protein (585 aa, 65 kDa) is encoded by the human LGALS3BP gene.
This protein plays a role in the positive regulation of integrin-mediated cell adhesion.;
NCIt note : Extracellular Galectin 3 Binding Protein contains an N-terminal MSR1 Cys-rich domain
and binds LGALS3 via carbohydrate-specific interaction. It is a potent stimulator
of host immune defense systems, such as NK and LAK cell cytotoxicity, and can induce
IL2 cytokine production. Oncogenic transformation, viral infection, or pathogen invasion
enhance LGALS3BP production. LGALS3BP is elevated in the serum of cancer and HIV patients.
(from LocusLink, OMIM, and NCI);
Origin ID : C26351;
UMLS CUI : C0217525;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_of
- gene_product_is_biomarker_type
- gene_product_plays_role_in_biological_process
