Growth/Differentiation Factor 8

Preferred Label : Growth/Differentiation Factor 8;

NCIt synonyms : GDF-8; GDF8; Myostatin; Growth Differentiation Factor-8;

NCIt definition : Growth/differentiation factor 8 (375 aa, 43 kDa) is encoded by the human MSTN gene. This protein plays a role in the negative regulation of skeletal muscle growth.;

NCIt note : The active growth factor is released from the precursor following proteolytic cleavage at arginine at amino acid position 266 which is the final amino acid in a polybasic proteolytic processing site. (EntrezGene and UniProt); Growth/Differentiation Factor 8 may be a treatment for cachexia in cancer patients.;

Details

Origin ID

C26328;

UMLS CUI

C0538238;

Currated CISMeF NLP mapping
- myostatin [MeSH Descriptor]
- myostatin [MeSH concept]
OMIM relation
- Myostatin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MSTN protein, human [MeSH Supplementary Concept]
- MSTN protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- MSTN Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Transforming Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Landogrozumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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