Inhibitor of Growth Protein 1

Preferred Label : Inhibitor of Growth Protein 1;

NCIt synonyms : Inhibitor of Growth Family Member 1; Inhibitor of Growth 1; ING1; Inhibitor of Growth-1 Protein;

NCIt definition : Inhibitor of growth protein 1 (422 aa, 47 kDa) is encoded by the human ING1 gene. This protein is involved in the regulation of the cell cycle.;

NCIt note : The ING1 protein physically interacts with p53 and appears necessary for the role of p53 in growth inhibition/apoptosis. ING1 shares many biological functions with p53 and has been reported to mediate growth arrest, senescence, apoptosis, anchorage-dependent growth, chemosensitivity, and DNA repair. Some of these functions, such as cell cycle arrest and apoptosis, have been shown to be dependent on the activity of both ING1 and p53 proteins. (from Leuk Res 2002;26:631-5 and Exp Cell Res 2002;279:291-8);

Details

Origin ID

C26291;

UMLS CUI

C1311255;

OMIM relation
- Inhibitor of growth 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ING1 protein, human [MeSH Supplementary Concept]
- ING1 protein, human [MeSH concept]
gene_encodes_gene_product
- ING1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Ligand Binding Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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