Four and a Half LIM Domains Protein 2

Preferred Label : Four and a Half LIM Domains Protein 2;

NCIt synonyms : Down-Regulated in Rhabdomyosarcoma LIM Protein; LIM Domain Protein DRAL; Four and a Half LIM Domains 2 Protein; SLIM-3; FHL-2; FHL2; Four and a Half LIM Domains 2; Skeletal Muscle LIM-Protein 3; Four and a Half LIM Domains-2 Protein;

NCIt definition : Four and a half LIM domains protein 2 (279 aa, 32 kDa) is encoded by the human FHL2 gene. This protein may play a role in both signal transduction and transcriptional regulation.;

NCIt note : Four and a half LIM domains protein 2 is a p53-responsive gene implicated in induction of apoptosis and expression of this protein results in enhancement of NF-kappaB activation.;

Details

Origin ID

C26198;

UMLS CUI

C1333635;

OMIM relation
- Four-and-a-half lim domains 2 [OMIM gene]
See also inter- (CISMeF)
- Hemophagocytic lymphohistiocytosis, familial, 2 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FHL2 protein, human [MeSH concept]
- FHL2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- FHL2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Coactivator [NCIt concept]
gene_product_has_structural_domain_or_motif
- LIM Domain [NCIt concept]
gene_product_is_element_in_pathway
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- HDAC Class III Signaling Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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