" /> Yttrium Y 90-Edotreotide - CISMeF





Preferred Label : Yttrium Y 90-Edotreotide;

NCIt synonyms : Yttrium Y 90 SMT 487; Yttrium Y 90-DOTA-Tyr3-Octreotide; Yttrium Y 90 -DOTATOC; 90Y-DOTA-3-Tyr-Octreotide; Yttrium Y 90-DOTA-3-tyrosine-octreotide;

NCIt related terms : EDOTREOTIDE YTTRIUM Y-90; yttrium Y 90 edotreotide;

NCIt definition : A radioconjugate consisting of the octreotide derivative edotreotide labeled with yttrium 90 (Y-90) with potential radiotherapeutic uses. Similar to octreotide, yttrium Y 90-edotreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells, delivering tissue-specific, beta-emitting nuclide Y-90-mediated cytotoxicity to SSTR-positive cells. Yttrium Y 90-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide and chelating the substituted octreotide to Y-90 via dodecanetetraacetic acid (DOTA).;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Yttrium Y 90 edotreotide contains yttrium Y 90 (a radioactive form of the metal yttrium) attached to a molecule that binds to certain types of neuroendocrine tumors (tumors that come from cells that release hormones). The radioactivity from yttrium Y 90 may kill the cancer cells.;

UNII : ABF7OG3FA3;

InChIKey : DUSFGVAHRFYHFD-CEKOMBBOSA-K;

CAS number : 322407-70-5;

Drug name : OctreoTher; Onalta;

Codes from synonyms : CDR0000258399; CDR0000044979; CDR0000580776;

PubMed : 20168290;

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07/05/2025


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