Signal Transducer and Activator of Transcription Family Gene

Preferred Label : Signal Transducer and Activator of Transcription Family Gene;

NCIt synonyms : STAT Family Gene;

NCIt definition : Signal Transducer and Activator of Transcription Family Genes encode dual function cytoplasmic Signal Transducer and Activator of Transcription (STAT) proteins that are activated by tyrosine phosphorylation in response to a large number of cytokines, growth factors, and hormones. After activation they form homodimers or heterodimers that translocate to the nucleus where they either bind directly to regulatory DNA cis-elements of specific target genes or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (NCI);

Details

Origin ID

C25991;

UMLS CUI

C1335960;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- STAT5 Protein Family [NCIt concept]
- Signal Transducer and Activator of Transcription [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_involved_in_molecular_abnormality
- Activating STAT1 Gene Mutation [NCIt concept]
- Activating STAT3 Gene Mutation [NCIt concept]
- Inactivating STAT1 Gene Mutation [NCIt concept]
- Inactivating STAT5B Gene Mutation [NCIt concept]
- Non-synonymous STAT Family Gene Mutation [NCIt concept]
- STAT Family Gene Mutation [NCIt concept]
- STAT1 Gene Mutation [NCIt concept]
- STAT3 Gene Mutation [NCIt concept]
- STAT5B Gene Mutation [NCIt concept]
- STAT5B NM_012448.3:c.1924A>C [NCIt concept]
- STAT6 Gene Mutation [NCIt concept]
gene_plays_role_in_process
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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