Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes

Preferred Label : Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes;

NCIt synonyms : Surface Glycoprotein, Ig Superfamily Member; ORCAM; CDON; CDON Protein; CDO; Surface Glycoprotein Ig Superfamily Member;

NCIt definition : Cell adhesion molecule-related/down-regulated by oncogenes (1287 aa, 139 kDa) is encoded by the human CDON gene. This protein is involved in the mediation of cellular adhesion.;

NCIt note : Surface Glycoprotein, Ig Superfamily Member, encoded by the human CDON gene, is a cell surface glycoprotein and a member of the immunoglobulin superfamily. Rhabdomyosarcoma is a childhood tumor of the skeletal muscle lineage in which cells display defects in both biochemical and morphological aspects of differentiation. The immunoglobulin superfamily members CDO and BOC are components of a cell surface receptor that positively regulates myogenesis in vitro. CDO and BOC may play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. (PubMed 12720294, LocusLink);

Details

Origin ID

C25891;

UMLS CUI

C1336539;

OMIM relation
- Cell adhesion molecule-related/downregulated by oncogenes [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- CDON Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Immunoglobulin Family Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Myogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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