Hsp90 Co-Chaperone CDC37

Preferred Label : Hsp90 Co-Chaperone CDC37;

NCIt synonyms : CDC37; CDC37 Homolog; Hsp90 Chaperone Protein Kinase-Targeting Subunit; p50Cdc37; CDC37 Protein; CDC37 Homolog Protein;

NCIt definition : Hsp90 co-chaperone Cdc37 (378 aa, 44 kDa) is encoded by the human CDC37 gene. This protein is involved in post-translational protein targeting.;

NCIt note : CDC37 Homolog, encoded by the CDC37 gene, is a protein highly similar to Cdc 37, which is a cell division cycle control protein of Saccharomyces cerevisiae. CDC37 Homolog is a molecular chaperone with specific function in cell signal transduction. It forms complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It plays a critical role in directing the chaperone HSP90 and targeting it to the CDK4 protein kinase, thereby promoting stability of CDK4 in regulating cell division cycle. (From LocusLink and NCI);

Details

Origin ID

C25803;

UMLS CUI

C1442787;

OMIM relation
- Cell division cycle 37, hsp90 cochaperone [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- CDC37 Gene [NCIt concept]
- Chaperone Protein Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- LKB1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Protein Folding [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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