C-C Chemokine Receptor-Like 2

Preferred Label : C-C Chemokine Receptor-Like 2;

NCIt synonyms : CCRL2 Protein; Chemokine (C-C Motif) Receptor-Like 2; CRAM-B; CKRX; CRAM-A; CCRL2; HCR; Putative MCP-1 Chemokine Receptor; Chemokine Receptor CCR11; Chemokine Receptor X; C-C Motif Chemokine Receptor-Like 2 Protein; Atypical Chemokine Receptor 5;

NCIt definition : C-C chemokine receptor-like 2 (344 aa, 40 kDa) is encoded by the human CCRL2 gene. This protein may play a role in the regulation of chemokine signaling.;

NCIt note : Chemokine (C-C Motif) Receptor-Like 2, encoded by the CCRL2 gene, is a seven transmembrane chemokine receptor like protein that is most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. (From LocusLink, OMIM); UniProt indicates that the CRAM-B isoform is the canonical sequence for C-C chemokine receptor-like 2.;

Details

Origin ID

C25789;

UMLS CUI

C1453427;

OMIM relation
- Chemokine, CC motif, receptor-like protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CCRL2 protein, human [MeSH concept]
- CCRL2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CCRL2 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Monocyte [NCIt concept]
- Neutrophil [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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