Chromosomal Translocation Process

Preferred Label : Chromosomal Translocation Process;

NCIt related terms : translocation;

NCIt definition : Any type of genetic recombination involving exchange of DNA between non-homologous chromosomes, which often occurs as the result of non-homologous end-joining of broken DNA strands. Chromosomal translocation is involved in repairing broken DNA and in maintaining cell viability at the expense of long term genomic stability. This process is is associated with particular types of leukemia, infertility and Down Syndrome.;

Alternative definition : NCI-GLOSS: A genetic change in which a piece of one chromosome breaks off and attaches to another chromosome. Sometimes pieces from two different chromosomes will trade places with each other. Translocations may lead to medical problems such as leukemia, breast cancer, schizophrenia, muscular dystrophy, and Down syndrome.;

Codes from synonyms : CDR0000470251;

Details

Origin ID

C25756;

UMLS CUI

C0040715;

Automatic exact mappings (from CISMeF team)
- MLLT6, PHD finger containing [HGNC gene]
- Translocations [LOINC Class]
Currated CISMeF NLP mapping
- Chromosomal translocation (morphologic abnormality) [SNOMED CT concept]
- Chromosome translocation [PASCAL descriptor]
- chromosomal translocation, nos [SNOMED Notion]
- translocation, genetic [MeSH Descriptor]
- translocation, genetic [MeSH concept]
See also inter- (CISMeF)
- chromosomal translocation [Disease (Nov.)]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- Chromosomal translocation (morphologic abnormality) [SNOMED CT concept]
- Chromosome translocation [PASCAL descriptor]
- chromosomal translocation [Disease (Nov.)]
- chromosomal translocation, nos [SNOMED Notion]
- translocation, genetic [MeSH Descriptor]
- translocation, genetic [MeSH concept]
biological_process_has_associated_location
- Translocation Breakpoint [NCIt concept]
biological_process_involves_gene_product
- X-Ray Repair Cross-Complementing Protein 5 [NCIt concept]
process_involves_gene
- XRCC5 Gene [NCIt concept]
- XRCC5 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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