Aspartate Aminotransferase

Preferred Label : Aspartate Aminotransferase;

NCIt synonyms : AST; Glutamic Oxaloacetic Transaminase; SGOT-AST Protein; AAT; ASAT; AspAT; EC 2.6.1.1; SGOT (AST); GOT;

NCIt related terms : SGOT; aspartate transaminase; serum glutamic-oxaloacetic transaminase;

NCIt definition : A family of pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. Aspartate aminotransferase specifically and reversibly catalyzes the transfer of an amino group from L-aspartate to alpha-ketoglutarate forming oxaloacetate and L-glutamate.;

Alternative definition : NCI-GLOSS: An enzyme found in the liver, heart, and other tissues. A high level of serum glutamic-oxaloacetic transaminase released into the blood may be a sign of liver or heart damage, cancer, or other diseases.;

NCIt note : Urea Cycle, Tricarboxylic Acid Cycle, Transamination;

Codes from synonyms : CDR0000372945; CDR0000372942; CDR0000372941;

Details

Origin ID

C25202;

UMLS CUI

C0242192;

Currated CISMeF NLP mapping
- Aspartate aminotransferase [LOINC component]
- Aspartate aminotransferase (substance) [SNOMED CT concept]
- SGOT [MedDRA LLT]
- SGOT [MeSH concept]
- aspartate aminotransferase [SNOMED Notion]
- aspartate aminotransferases [MeSH Descriptor]
- aspartate aminotransferases [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SGOT [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein Metabolism Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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