LMB-1 Immunotoxin

Preferred Label : LMB-1 Immunotoxin;

NCIt synonyms : B3-NLysPE38; Immunotoxin LMB-1; LMB-1;

NCIt definition : A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI04);

Alternative definition : NCI-GLOSS: A toxic substance linked to an antibody that attaches to tumor cells and kills them.;

NSC code : 651311;

Codes from synonyms : NSC0651311; CDR0000046141;

Details

Origin ID

C2499;

UMLS CUI

C0796420;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Elongation Factor 2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Lewis Y Antigen Binding [NCIt concept]
- Mitochondrial Damage [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Translational Repression [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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