" /> LMB-9 Immunotoxin - CISMeF





Preferred Label : LMB-9 Immunotoxin;

NCIt synonyms : LMB-9; B3 (dsFv)-PE38; Immunotoxin LMB-9;

NCIt definition : A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.;

Alternative definition : NCI-GLOSS: A toxic substance linked to an antibody that attaches to tumor cells and kills them.;

NSC code : 691236;

Codes from synonyms : CDR0000045968;

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15/05/2024


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