Prothymosin Alpha

Preferred Label : Prothymosin Alpha;

NCIt synonyms : PTMA;

NCIt definition : Prothymosin alpha (111 aa, 12 kDa) is encoded by the human PTMA gene. This protein may play a role in the regulation of apoptosis.;

NCIt note : Encoded by human PTMA Gene, 110-aa 12-kDa (precursor) highly acidic (54/111 residues) conserved Prothymosin Alpha may be linked covalently to a small RNA; may be involved in ultraviolet irradiation-induced apoptosis; contains N-terminal thymosin-alpha-1 (28-aa) sequence; and may mediate immune function and confer resistance to opportunistic infections. While PHAP promotes caspase-9 activation after apoptosome formation, PTMA inhibits apoptosome formation and caspase-9 activation; caspase-3 activator PETCM relieves PTMA inhibition of apoptosome formation.; Prothymosin alpha is an abundant mammalian acidic nuclear protein whose expression is related to cell proliferation. An association between ProT alpha levels with increase in risk of death from breast cancer has been noticed.; Prothymosin alpha can be cleaved to release thymosin alpha-1. (UniProt);

Details

Origin ID

C2279;

UMLS CUI

C1527417;

Currated CISMeF NLP mapping
- prothymosin alpha [MeSH concept]
- prothymosin alpha [MeSH Supplementary Concept]
OMIM relation
- Prothymosin, alpha [OMIM gene]
See also inter- (CISMeF)
- Prothymosin, alpha [OMIM gene]
- prothymosin alpha [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- PTMA Gene [NCIt concept]
gene_product_expressed_in_tissue
- Thymus Gland [NCIt concept]
gene_product_has_biochemical_function
- Thymosin Family [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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