Preferred Label : Allopurinol;
NCIt synonyms : 4-Hydroxypyrazolo[3,4-d]pyrimidine; 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one; 4'-HPP; Zurinol;
NCIt related terms : 1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 1H-Pyrazolo[3,4-d]pyrimidin-4-ol;
NCIt definition : A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme
that converts oxypurines to uric acid. By blocking the production of uric acid, this
agent decreases serum and urine concentrations of uric acid, thereby providing protection
against uric acid-mediated end organ damage in conditions associated with excessive
production of uric acid, i.e. the massive cell lysis associated with the treatment
of some malignancies. (NCI04);
Alternative definition : NCI-GLOSS: A drug that lowers high levels of uric acid (a byproduct of metabolism)
in the blood caused by some cancer treatments.;
UNII : 63CZ7GJN5I;
InChIKey : OFCNXPDARWKPPY-UHFFFAOYSA-N;
CAS number : 315-30-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 315-30-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Sigapurol; Lopurin;
Chemical formula : C5H4N4O;
NSC code : 101655; 1390;
ChEBI ID : CHEBI:40279;
Codes from synonyms : NSC0001390; 02339; CDR0000045052; 21;
Origin ID : C224;
UMLS CUI : C0002144;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
