Description : Hereditary pyropoikilocytosis was originally described by Zarkowsky et al. (1975)
as a distinct hemolytic anemia characterized by microspherocytosis, poikilocytosis,
and an unusual thermal sensitivity of red cells. HPP is a subset of hereditary elliptocytosis
(see 611804) due to homozygous or compound heterozygous mutations in spectrin leading
to severe disruption of spectrin self-association (review by An and Mohandas, 2008).;