Cleavage and Polyadenylation Specificity Factor Subunit 5

Preferred Label : Cleavage and Polyadenylation Specificity Factor Subunit 5;

NCIt synonyms : Pre-mRNA Cleavage Factor Im 25 kDa Subunit; Nucleoside Diphosphate-Linked Moiety X Motif 21; NUDT21; CPSF 25 kDa Subunit; Nudix Motif 21; Nudix Hydrolase 21; Cleavage Factor Im Complex 25 kDa Subunit; CFIm25; Cleavage and Polyadenylation Specificity Factor 25 kDa Subunit;

NCIt definition : Cleavage and polyadenylation specificity factor subunit 5 (227 aa, 26 kDa) is encoded by the human NUDT21 gene. This protein is involved in the recruitment of multiprotein complexes to the cleavage and polyadenylation signals (pA signals) on the 3'-end of pre-mRNA.;

NCIt note : Cleavage and polyadenylation specificity factor subunit 5 is missing the conserved metal-binding residues in the NUDIX motif; therefore, it does not have hydrolase activity. (UniProt);

Details

Origin ID

C218425;

OMIM relation
- Nudix hydrolase 21 [OMIM gene]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- NUDT21 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Scaffolding Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Nucleotide Metabolic Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- RNA Processing [NCIt concept]
- mRNA Surveillance [NCIt concept]
is_target
- NUDT21-targeted siRNA [NCIt concept]

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