Preferred Label : NUDT21-targeted siRNA;
NCIt synonyms : NUDT21 siRNA; NUDT21-targeting siRNA;
NCIt definition : A formulation composed of small-interfering RNAs (siRNAs) directed against the oncogene
NUDT21 (cleavage factor Im complex 25 KDa subunit; cleavage and polyadenylation specificity
factor subunit 5; CFIM25; CPSF5; nudix hydrolase 21), with potential antineoplastic
activity. Upon administration of NUDT21-targeted siRNA, the siRNA binds to NUDT21
mRNA, which may result in the inhibition of translation and expression of the NUDT21
protein and leads to apoptosis and growth inhibition in tumor cells that overexpress
NUDT21. NUDT21, an enzyme that belongs to the Nudix family of hydrolases, plays a
key role in growth and metastasis in a variety of cancers. NUDT21 regulates the 3'UTR
plus tail of the protein structural maintenance of chromosomes protein 1A (SMC1A),
which plays a key role in tumor development of certain types of cancer.;
Origin ID : C217332;
concept_is_in_subset
- has_target
