mRNA Surveillance

Preferred Label : mRNA Surveillance;

NCIt definition : mRNA Surveillance works within elaborate cellular mechanisms to ensure accurate gene expression by assessing suitable mRNA quality for translation and prevents the synthesis of truncated or aberrant proteins. By nonsense-mediated decay, mRNA surveillance facilitates the detection and destruction of mRNAs that contain premature termination codons. Also, by nonstop decay, mRNA surveillance depletes mRNAs that lack in-frame termination codons.;

Details

Origin ID

C29645;

UMLS CUI

C1515671;

Semantic type(s)
- Genetic Function [UMLS semantic type]
biological_process_involves_gene_product
- Cold Shock Domain-Containing Protein E1 [NCIt concept]
- Polyadenylate-Binding Protein 2 [NCIt concept]
- Protein Pelota Homolog [NCIt concept]
- Serine/Threonine-Protein Kinase SMG1 [NCIt concept]
process_involves_gene
- CSDE1 Gene [NCIt concept]
- CSDE1 wt Allele [NCIt concept]
- PABPN1 Gene [NCIt concept]
- PABPN1 wt Allele [NCIt concept]
- PELO Gene [NCIt concept]
- PELO wt Allele [NCIt concept]
- SMG1 Gene [NCIt concept]
- SMG1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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