DNA Topoisomerase 2-Binding Protein 1

Preferred Label : DNA Topoisomerase 2-Binding Protein 1;

NCIt synonyms : TOPBP1; Hypothetical Protein KIAA0259; Topoisomerase (DNA) II Binding Protein; KIAA0259; DNA Topoisomerase II-Beta-Binding Protein 1; DNA Topoisomerase-II Binding Protein; DNA Topoisomerase II-Binding Protein 1; DNA Topoisomerase II Binding Protein; DNA Topoisomerase II Binding Protein 1;

NCIt definition : DNA topoisomerase 2-binding protein 1 (1522 aa, 171 kDa) is encoded by the human TOPBP1 gene. This protein is involved in both DNA replication and the repair of nicked DNA.;

NCIt note : TOPBP1 interacts with the C-terminal region of topoisomerase II beta and may stimulate its catalytic activity through transient breakages of DNA strands. (EntrezGene);

Details

Origin ID

C21545;

UMLS CUI

C0671110;

OMIM relation
- Dna topoisomerase II-binding protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- TOPBP1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BRCT Domain [NCIt concept]
gene_product_is_element_in_pathway
- BARD1 Signaling Pathway [NCIt concept]
- E2F Transcription Factor Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]

Keyword's position in hierarchy(ies) :

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