Preferred Label : Breast Cancer Anti-Estrogen Resistance 3 Protein;
NCIt synonyms : BCAR3; SH2 Domain-Containing Protein 3B; Breast Cancer Anti-Estrogen Resistance 3; Novel SH2-Containing Protein 2; Breast Cancer Anti-Estrogen Resistance-3 Protein;
NCIt definition : Breast cancer anti-estrogen resistance protein 3 (825 aa, 93 kDa) is encoded by the
human BCAR3 gene. This protein may be involved in receptor-mediated signaling.;
NCIt note : Encoded by human BCAR3 Gene, the 92.6 kD 825-amino acid BCAR3 Protein contains a putative
SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous
to CDC48 (Yeast). Abundant expression is seen in heart, placenta, skeletal muscle,
spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several
cancer cell lines, but not in nonmalignant breast tissue. NSP2 induces anti-estrogen
resistance in estrogen-dependent breast tumors. (SWISS-PROT, OMIM);
Origin ID : C21496;
UMLS CUI : C1309026;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
