Annexin A5 - CISMeF

Preferred Label : Annexin A5;

NCIt synonyms : PAP-I; ANXA5; Annexin V; Placental Protein 4; Thromboplastin Inhibitor; CBP-I; Calphobindin I; VAC-Alpha; Lipocortin V; Anchorin CII; PP4; Endonexin II; Placental Anticoagulant Protein I; Vascular Anticoagulant-Alpha; Placental Anticoagulant Protein 4; Annexin-5; Annexin-A5 Protein;

NCIt definition : Annexin A5 (320 aa, 36 kDa) is encoded by the human ANXA5 gene. This protein plays a role in the inhibition of blood coagulation and the transmembrane transport of calcium.;

NCIt note : Annexin A5 contains 4 annexin repeats; some of which may bind calcium and phospholipid. PP4 forms a voltage-dependent membrane Ca(2 ) channel; key amino acids act as selectivity filters and voltage sensors, regulating pore permeability to ions. As an anticoagulant protein, PP4 acts as an indirect inhibitor of the blood coagulation cascade thromboplastin-specific complex. (OMIM, Swiss-Prot);

UNII : Y21YS63R90;

CAS number : 117216-75-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 117216-75-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Details

Origin ID

C21333;

UMLS CUI

C4048686;

Currated CISMeF NLP mapping
- Annexin A5 (substance) [SNOMED CT concept]
- Placental protein 4 (substance) [SNOMED CT concept]
- annexin A5 [MeSH Descriptor]
- annexin A5 [MeSH concept]
OMIM relation
- Annexin a5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
gene_encodes_gene_product
- ANXA5 Gene [NCIt concept]
- Ion Channel Protein Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Placenta [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Ion Channel [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Annexin Family Protein [NCIt concept]
- Calcium Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Binding [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Coagulation [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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