" /> ABL Interactor 2 - CISMeF





Preferred Label : ABL Interactor 2;

NCIt synonyms : ABI2; ABL Binding Protein 3; ABL-Interactor Protein 2B; ArgBP1; Abi-2; Abl-Binding Protein 3; Arg-Binding Protein 1; Abelson Interactor 2; AblBP3; ABL-Interacting Protein 1; ABL-Interactor 2 Protein; Arg Protein Tyrosine Kinase-Binding Protein;

NCIt definition : ABL interactor 2 (513 aa, 56 kDa) is encoded by the human ABI2 gene. This protein plays a role in the regulation of both signal transduction and cell growth.;

NCIt note : The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. ABL-Interactor 2, encoded by the ABI-2 gene, is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. (LocusLink and OMIM);

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30/04/2024


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