Preferred Label : Anti-mucin-1/CD16A Bispecific Antibody BGB-B3227;
NCIt synonyms : Anti-mucin-1/Anti-CD16A Bispecific Antibody BGB-B3227; Anti-Muc1 NK Cell Engager BGB-B3227; Anti-MUC1/CD16A Bispecific Antibody BGB-B3227; MUC1 x CD16A Bispecific Antibody BGB-B3227;
NCIt definition : An immunoglobulin G1 (IgG1) humanized bispecific antibody directed against the tumor
associated antigen (TAA) mucin-1 (MUC1) and the human low affinity IgG Fc region receptor
IIIA (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-MUC1/CD16A bispecific antibody BGB-B3227 targets and binds
to CD16A expressed on natural killer (NK) cells and MUC1 expressed on the surface
of tumor cells, thereby selectively cross-linking tumor and NK cells. This may result
in NK cell activation and eventually tumor cell lysis. CD16A is specifically expressed
on the surface of NK cells. MUC1, a glycoprotein overexpressed on the surface of a
variety of cancer cells, plays a key role in tumor cell survival and proliferation.;
Molecule name : BGB B3227; BGB-B3227;
Origin ID : C212878;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
