A Disintegrin and Metalloprotease with Thrombospondin Motifs 1

Preferred Label : A Disintegrin and Metalloprotease with Thrombospondin Motifs 1;

NCIt synonyms : ADAM-TS1; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1; METH-1; ADAMTS1; ADAMTS-1; ADAM-TS 1; A Disintegrin and Metalloprotease with Thrombospondin Motifs-1; EC 3.4.24.-; ADAMTS1 Protein;

NCIt definition : A disintegrin and metalloproteinase with thrombospondin motifs 1 (967 aa, 105 kDa) is encoded by the human ADAMTS1 gene. This protein plays a role in both proteolysis and integrin-mediated signaling.;

Details

Origin ID

C21277;

UMLS CUI

C1307941;

OMIM relation
- A disintegrin-like and metalloproteinase with thrombospondin type 1 motif, 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ADAMTS1 protein, human [MeSH concept]
- ADAMTS1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- ADAMTS1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
- Peptidase Family M12B [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Disintegrin Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients