14-3-3 Family - CISMeF

Preferred Label : 14-3-3 Family;

NCIt synonyms : 14-3-3 Family;

NCIt definition : The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Two different binding motifs, RSXpSXP and RXY/FXpSXP, are present in nearly all known 14-3-3 binding proteins. The 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM);

Details

Origin ID

C21256;

UMLS CUI

C1337047;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_product_has_biochemical_function
- Adaptor Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- RSXpSXP Motif [NCIt concept]
- RXY/FXpSXP Motif [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
is_chemical_classification_of_gene_product
- 14-3-3 Protein Epsilon [NCIt concept]
- 14-3-3 Protein Theta [NCIt concept]
- 14-3-3 Protein Zeta/Delta [NCIt concept]

Keyword's position in hierarchy(ies) :

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