Preferred Label : RXY/FXpSXP Motif;
NCIt synonyms : RXY/FXpSXP Domain; RXY FXpSXP Motif;
NCIt definition : The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing
proteins. RXY/FXpSXP Motif is one of two different binding motifs that are present
in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single
molecules containing tandem repeats of phosphoserine motifs, implicating bidentate
association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from
OMIM);
Origin ID : C13976;
UMLS CUI : C1514675;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
